The Incidence of Acute Kidney Injury (AKI) in Critically Ill COVID-19 Patients: A Single-Center Retrospective Cohort Study at a Tertiary Level Hospital in Oman

Background: Acute kidney injury (AKI) is associated with adverse outcomes in critically ill patients. Coronavirus disease 2019 (COVID-19) affects the renal system frequently and leads to AKI. This study aims determine incidence of AKI, risk factors including hyperglycemia, requirement for dialysis. Methods: A retrospectively observational was done at Sultan Qaboos University Hospital between March 2020 September 2021. total 286 adult patients laboratory-confirmed COVID-19 infection admitted intensive care unit (ICU) were included study. The patient’s medical records reviewed. Patients’ baseline demographic characteristics, APACHE score on admission, clinical data length stay, oxygenation parameters, ventilator days, shock, AKI (KIDIGO guideline), dialysis, medications, lab admission as well during ICU outcome (mortality) recorded detail. Follow-up till discharge from ICU. Results: population 68.5% (196/286) males. median age 56 years (interquartile range, IQR: 43-66.25). 55.2% (158/286) overall. Out those who had 27.2% (43/158), 31.6% (50/158), 41.1% (65/158) developed stages 1, 2, 3, respectively. Univariate analysis development showed following significant variables: (p=0.005; odds ratio, OR 1.024; 95% confidence interval, CI 1.007-1.041), creatinine level (p=0.012; 1.005; 95%CI 1.001-1.008), (p<0.001; 1.049; 1.021-1.077), P/F ratio 0.991; 0.987-0.995), nephrotoxic agent 8.556; 4.733-15.467), shock 8.690; 5.087-14.843), days 1.085; 1.043-1.129), stay 1.082; 1.047-1.119). multivariate confirmed only (p=0.004; 5.893; 1.766-19.664). 41.7% (66/158) received Hyperglycemia not For having high (p<0.001), (p=0.56; 2.326; 1.036-5.223), ischemic heart (IHD) (p=0.002; 9.000; 1.923-42.130), hypertension (p=0.023; 2.145; 11.125-4.090) significantly mortality found be 59.1% (169/286) overall whereas it 83.5% (132/158) versus 28.9% (37/158) non-AKI cases. Conclusions: cases this predictor these